Project 4: Biocompatibility, Biodistribution, and Neurotoxicity of Nanostructured Elements.(IN1, FB3).
Description and objectives:
We characterize the biocompatibility and biodistribution of nanostructured elements, especially the immune response to them, its neurotoxicity and biodistribution in the body, using animal models (mouse and rat). This project continues the collaboration already established between these groups, with a vaccine consisting of nanostructures that contain viral particles, together with Dr. María José Alonso (USC). Moreover, it will be considered the effect on the nervous system. Also, it would be possible to incorporate new nanostructures of different origins, either commercial or synthesized by other groups.
The objective is to determine whether these nanostructures are able to:
In the case of vaccines,
1. Facilitate the transport of bound antigen through mucosal surfaces, such as the nasal cavity, obtaining a system for vaccine delivery, needle away.
2. Enhance and prolong the immune response generated by the viral antigen, resulting in a reduction in the number of doses to be administered.
In the case of nanostructured elements,
1. Asses the biodistribution of the nanoparticles, determining the placement in local tissues and vital organs, and absorption rate after administration on mucosal surfaces.
2. Asses the neurotoxicity of the nanostructures.
This work is carried out in collaboration with the Hospital Complex of Vigo (CHUVI), particularly with Hematology, Immunology, Endocrinology, and Pathology Units.