We aim at creating a stable and quality driven research cluster in Biomedicine.

Research Frame.

AREA 2: NEW DIAGNOSTIC TECHNIQUES.

2A. Biomarkers.
 Groups: FB3, BB1, CI8, SI4, IN1, QF1.

 OBJECTIVES:
- Development of genetic markers for the diagnosis of hereditary diseases and study the role of certain polymorphisms in the expression of pathology using "Genome Wide Association Studies" with high performance platforms and chips designed for the identification of numerous single base polymorphisms.
- New biochemical markers for monitoring differentiated thyroid cancer and presence of anti-Tg. Development of open source tools for classifying patients based on data from DNA microarrays. Development of bioinformatics tools that allow easy handling of results of DNA microarray and protein and cytometric techniques CBA (cytometric bed array). Multivariate Statistical evaluation of the results obtained with panels of markers.
- Development of immunosensors for tumor detection

2B. Ultra-rapid detection and single-molecule.
 Groups: QF1, BB1, QO1, SI4, CI8.

 OBJECTIVES:
- Development of new biosensors nanoparticles as molecular recognition with high sensitivity and productivity with applications in diagnostics and detection. Each of the particles will be functionalized with a specific marker for a pathogen, a tumor or another disease. The microparticles are placed in direct contact with biological fluid or be arranged on a microarray. After washing, it is treated with a solution of a fluorescent screening marker (antibody or antigen) following ultrasensitive analysis by Raman spectroscopy.
- Detection of single molecules in high-performance multiplex screening and use in biomedicine. The group of Luis Liz and Ramón Alvarez Puebla has recently developed a new technology for detecting particles and individual molecules (with sensitivity level zeptomol -10-21-). The Association will discuss the development of applications for biomolecule detection using SERS (surface-enhanced Raman scattering) and SERRS (surface-enhanced resonance Raman scattering), which requires the construction of the corresponding molecular interfaces combinatorially (antibodies, antigens, nucleic acids).

2C. Proteomic analysis by immunoaffinity.
 Groups: CI8, BB1, QF1, SI4, IN1.

 OBJECTIVES:
- Immunochemical analysis of the proteome: extracting and enrichment of minor proteins present in cell tissues by immunoaffinity chromatography.