Computational Genomics Research Group (XB5).
Main paths of collaborations and partnerships with Hospitals and other Institutions in biomedicine, include:
- Harvard Medical School (Cambridge, MA, USA),
- Institute for Computational Medicine at Johns Hopkins University (Baltimore, MD, USA),
- National Cancer Institute at Frederick (Frederick, MD, USA),
- National Institute of Allergy and Infectious Diseases (National Institutes of Health, Bethesda, MD, USA),
- Columbia University College of Physicians and Surgeons and Harlem Hospital Center (NY, USA),
- CiberOBN (Networked Biomedical Research Center-Pathophysiology of Obesity and Nutrition),
- Human Genetics Center, University of Texas Health Science Center (Houston, TX, USA),
- Department of Human Genetics, University of Michigan School of Medicine, (Ann Arbor, MI, USA ),
- KTL-National Public Health Institute (Helsinki, Finland),
- Tropical Medicine Institute (Havana, Cuba).
- Also, with international biomedical companies:
VaxGen, Inc., Presidio Pharmaceuticals, Inc. and Global Solutions for Infectious Diseases, Inc; all located in San Francisco, (CA, USA).
Nationally, the group collaborates with the National Center for Microbiology (CNM) of Instituto Carlos III, Madrid, in the detection of mosaic genomes of HIV-1 and characterization of the virus evolutionary markers that explain the progression of the disease.
The group is also part of the Shared Unit UVIGO-SERGAS of Research in Translational Bioinformatics (InBiT), where the effort is focused on the application of knowledge and skills to the development and deployment of new services in the hospital setting.
The group of Prof. David Posada develops several lines of biomedical computational research related to bioinformatics, genetics and genomics, including applications in pharmacogenetics, and epidemiology of infectious diseases, primarily AIDS.
Notably, the group has developed methods for associative studies genotype / phenotype, through which has evaluated the effect of different single nucleotide polymorphisms (SNPs) of the apolipoprotein E gene (APOE) on the levels of lipids and the reduction effect of different statins.
Furthermore, the group has conducted numerous studies of epidemiology of the AIDS virus, funded by MEC, with potential applications in the development of an AIDS vaccine, including the genome of the virus, following the first clinical assay phase III, with the company VaxGen, Inc. (USA).
In addition, group members are identifying SNPs associated with deleterious mutations in genes responsible for human diseases such as cancer (p53 gene).
As a sign of quality, it is noteworthy that the group leader is the only galician obtaining a project within european IDEAS program so far, his articles have been very highly cited, being the spaniard, along with Mariano Barbacid, included in the top 30 ISI Highly Cited Researchers in "Molecular Biology & Genetics".