We aim at creating a stable and quality driven research cluster in Biomedicine.

Nanomedicine Research Group (QF1). (WEB)

Main lines of research of this Physical Chemistry group, related to Nanomedicine, are:

- Search for biomolecules that may be useful marker in early diagnosis of cancer, prognostic markers for predicting the evolution of the patient and aftercare markers that allow tracking the evolution of the patient and determine the effectiveness of treatment.

Coordinating a working group associated with nanoparticles for diagnosis and therapy, also participating in another one in which actively collaborates with Prof. Africa Gonzalez, conducting studies of response of macrophages and tumor cells in the presence of several types of nanoparticles, with the primary objective of determining toxic effects of nanoparticles and the immune system response.

- Nanotechnology applications in biomedicine, NANOBIOMED (CSD2006-12-1), Consolider-Ingenio 2010 program.

Prof. Luis Liz is coordinating a working group associated with nanoparticles for diagnosis and therapy, also participating in another one in which actively collaborates with Prof. Africa Gonzalez, conducting studies of response of macrophages and tumor cells in the presence of several types of nanoparticles, with the primary objective of determining toxic effects of nanoparticles and the immune system response.

- Rede Galega de Nanomedicina (2007/000006-0)

This Galician Network, coordinated by Prof. Liz, was established in 2007 to open a multidisciplinary approach to nanomedicine, facilitating communication among diverse groups to raise Galician research in this area. This network is composed of physicians, chemists, physicists, including groups of the cluster like the ones of Prof. Africa Gonzalez (Immunology) and Prof. Federico Mallo (Physiology). Thanks to collaborations arising under this network, there have been several communications in international and national conferences (XXXIV Congress of the Spanish Society of Immunology, "NanoSpain 2008. Nanoiberian Conference", Nanotech Northern Europe 2008) and several articles are under way.

- Biosensors based on metal nanoparticles with controlled size and shape (PCI2005-A7-0075).

Studies have been developed in collaboration with the group of Prof. Paul Mulvaney (U. of Melbourne, Australia), for the synthesis and characterization of noble metal nanoparticles with controlled size and shape and its surface modification and organization to lead to nanostructured materials. The in situ study of the optical response during the interaction of biomolecules was used to estimate the efficiency of these nano-systems as biosensors with potential application in new therapies.

- Rational Design of biosensors based on metal nanoparticles (MAT2007-626969).

This project involves a systematic study of the application of nanoparticles for the development of new highly sensitive biosensors, which could vary according to the characteristics of these nanoparticles. To fulfill this goal, there are ongoing studies of nanoparticle deposition on substrates and nanometals used as biosensors. This project requires partnerships with other groups in the biomedical industry, which will lead to new collaborations within the cluster.

- Implementing enhanced surface spectroscopy (SERS and SEF) and composite microparticles (SiO2/Nanoparticle) to drug discovery with biological activity, diagnosis and examination (MAT2008-05755).

The aim of this project is the development of functionalized active metallic nanostructures for surface enhanced spectroscopy (SERS and SEF) on silica microspheres. These hybrid materials will be used in drug design and development of new sensors for diagnostics and biosensing. For the development of this project has already started work with the groups of Prof. Africa Gonzalez, and Prof Rodriguez de Lera, who would be responsible for bioorganic modification of nanoparticles.

- Ultrasensitive nanobiosensors based on SERS for diagnostics and biosensing (08TMT008314PR).

This project should enhance convergence and interdisciplinary collaboration in nanotechnology, biotechnology and medicine, with the aim of integrating the latest advances in these fields and develop new nanobiosensors of higher sensitivity and specificity. The nanoparticles, modified with proteins, are used in various studies as biomarkers of diseases of interest and study of the Association.

- Nanoparticles in biological systems: immune response and diagnosis (PGIDIT06TMT31402PR/01).

Together with Prof. Jos´e; Faro (Immunology Group) aims to develop nanoparticles that can be used in diagnostic techniques, in vitro and in vivo, and also in vaccination and human therapy. For efficient project development and achievement of results is necessary collaboration with the various groups of the Association: physical chemists, organic chemists, immunologists and physicians.

Description:

The group of Prof. Luis M. Liz Marzan has increased significantly in recent years his renown, both nationally and internationally. Among the most outstanding merit may be mentioned his appointment as a Fellow of the Royal Society of Chemistry; his recent award of Physical Chemistry of the Spanish Royal Society of Chemistry; and, the award of Junior Research Galicia to Dr. Miguel A. Duarte Correa.

A sample of the quality of its publications is given by the 1,000 cites per year and have been chosen to illustrate the covers of high impact journals such as Nature Materials, Angewandte Chemie and Advanced Materials, among others. You could say that this is one of the groups most internationally Spanish and impact in the field of nanotechnology.

Moreover, between 2006 and 2008, the group has had remarkable success in competitive calls from European, national and regional side. Group members have been invited to give over 50 presentations and to be part of several editorial boards of prestigious journals such as Nano Today, Journal of Physical Chemistry, and Journal of Materials Chemistry, among others. Note that at the end of 2008, IP Group has been named Senior Editor of the Journal of the American Chemical Society Langmuir.