Endocrinology and Neuroscience Research Group (FB3)
Main lines of research in Endocrinology.
- Incretines and its therapeutic effect in diabetes and obesity. GLP-1, Exendin, DPPIV
- Control of food intake in diabetes and obesity
- Control of neuroendocrine function in diabetes: somatotropic, corticotropic and gonadotroph axis.
Main lines of research in Neuroscience.
- role of ion channels in normal and pathological neuronal behavior
The group coordinated by Prof. Federico Mallo Ferrer has broad experience in the study of more prevalent metabolic diseases in the West: diabetes and obesity, especially in the pathophysiological control of food intake in these pathologies. These studies range from basic perspective on animal models to understand the physiological mechanisms underlying translational studies in human subjects from a pathophysiologic and therapeutic perspective. In recent years the main line of research has focused on identifying the mechanism of action of novel insulinotropic molecules of the GLP-1 family, of therapeutic application due to its anorexigenic effect and modulating other neuroendocrine axes, such as the adrenal and the gonadotroph. It also collaborates with other groups in the development of new pharmaceutical formulations for therapeutic administration of insulinotropic substances in diabetes and obesity. The current research areas are:
Besides, through the Shared Research Unit with Clinical Analysis and Endocrinology Units at Hospital Xeral-Cies in Vigo and Endocrinology Unit at Montecelo Hospital in Pontevedra, most of these lines are developed in clinical settings applied to endocrine diseases such as Diabetes, Obesity and Acromegaly. Specifically:
- Hormonal Changes in extreme situations in subjects admitted to the ICU: Ghrelin and interaction with the cortico-adrenal axis.
- neuroendocrine effects of incretins: GLP-1 and related substances, super-analogues (Exendin-4) or enzyme inhibitors of DPP-IV. Somatotroph and gonadotroph axis. Role in diabetes and obesity.
- Acromegaloidism, characterization of genetic and metabolic disorders, identification of cardiovascular risk and morbidity and mortality.
- Differentiated Thyroid Cancer (DTC) and biochemical markers for monitoring. Use of thyroglobulin (Tg) in washing of needles of FNA (Fine Needle Aspiration Biopsy) as an aid in the diagnosis of lymph node metastases. Search for alternative markers for biochemical monitoring of patients with DTC and presence of anti-Tg.
The group led by Prof. José Antonio Lamas Castro specializes in studying the nervous system from the molecular, cellular and systems point of view. This group mainly uses electrophysiological techniques, PCR and immunocytochemistry.
The group pursues to understand the role of ion channels in normal and pathological neuronal behavior.
It studies potassium, sodium and cationic channels, all of great importance in regulating neuronal excitability, but also related to a number of diseases such as Alzheimer's, epilepsy, sclerosis, etc.. In this line, it is addressed the effect of drugs used in the treatment of these diseases (riluzole, valproate), or in the preclinical phase (linopirdine) on the behavior of neurons in culture. This group is particularly interested in the study of channelopathies, mutations of genes that express ion channels and affecting the functioning of those causing diseases such as epilepsy, ataxia, paralysis, myopathy, long QT syndrome (LQTS), among others. The relationship between clinical research groups will allow research into new drugs of therapeutic interest for treating diseases of the nervous system, especially in the emerging field of channelopathies.
Despite the small size of the group, it has been continuously funded through national and international calls, such as CONSOLIDER project.